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P24593

Insulin-like growth factor-binding protein 5 (P24593)

Uniprot ID P24593
Protein Name Insulin-like growth factor-binding protein 5
Gene Name IGFBP5
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.932
Function IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
GO - Molecular function
  • fibronectin binding : IBA:GO_Central
  • insulin-like growth factor I binding : IPI:BHF-UCL
  • insulin-like growth factor II binding : IBA:GO_Central
GO - Biological process
  • aging : IEA:Ensembl
  • cellular protein metabolic process : TAS:Reactome
  • cellular response to cAMP : IDA:UniProtKB
  • cellular response to organic cyclic compound : IDA:UniProtKB
  • female pregnancy : IEA:Ensembl
  • glucose homeostasis : IEA:Ensembl
  • hair follicle morphogenesis : IEA:Ensembl
  • intracellular signal transduction : IEA:Ensembl
  • lung alveolus development : IEA:Ensembl
  • mammary gland involution : IEA:Ensembl
  • negative regulation of cell migration : IDA:BHF-UCL
  • negative regulation of growth : IEA:Ensembl
  • negative regulation of insulin-like growth factor receptor signaling pathway : IDA:BHF-UCL
  • negative regulation of muscle tissue development : IEA:Ensembl
  • negative regulation of osteoblast differentiation : IEA:Ensembl
  • negative regulation of skeletal muscle hypertrophy : IEA:Ensembl
  • negative regulation of smooth muscle cell migration : IDA:BHF-UCL
  • negative regulation of smooth muscle cell proliferation : IDA:BHF-UCL
  • negative regulation of translation : IDA:BHF-UCL
  • osteoblast differentiation : IEA:Ensembl
  • positive regulation of insulin-like growth factor receptor signaling pathway : IEA:Ensembl
  • positive regulation of protein kinase B signaling : IEA:Ensembl
  • positive regulation of vascular associated smooth muscle cell migration : IGI:BHF-UCL
  • positive regulation of vascular smooth muscle cell proliferation : IGI:BHF-UCL
  • post-translational protein modification : TAS:Reactome
  • regulation of cell growth : IEA:Ensembl
  • regulation of insulin-like growth factor receptor signaling pathway : IBA:GO_Central
  • response to growth hormone : ISS:AgBase
  • signal transduction : NAS:ProtInc
  • striated muscle cell differentiation : IEA:Ensembl
  • type B pancreatic cell proliferation : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.