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P24592

Insulin-like growth factor-binding protein 6 (P24592)

Uniprot ID P24592
Protein Name Insulin-like growth factor-binding protein 6
Gene Name IGFBP6
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.722
Function IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
GO - Molecular function
  • fibronectin binding : IBA:GO_Central
  • insulin-like growth factor I binding : IBA:GO_Central
  • insulin-like growth factor II binding : IMP:CAFA
  • signaling receptor binding : TAS:ParkinsonsUK-UCL
GO - Biological process
  • cellular protein metabolic process : TAS:Reactome
  • negative regulation of canonical Wnt signaling pathway : TAS:ParkinsonsUK-UCL
  • negative regulation of cell population proliferation : TAS:ProtInc
  • regulation of insulin-like growth factor receptor signaling pathway : IBA:GO_Central
  • signal transduction : NAS:ProtInc
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.