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P24468

COUP transcription factor 2 (P24468)

Uniprot ID P24468
Protein Name COUP transcription factor 2
Gene Name NR2F2
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.532
Function Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. .
GO - Molecular function
  • DNA binding transcription factor activity : IDA:UniProtKB
  • nuclear receptor activity : IDA:UniProtKB
  • protein homodimerization activity : IPI:UniProtKB
  • retinoic acid binding : IDA:UniProtKB
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding : ISM:NTNU_SB
  • sequence-specific DNA binding : IDA:UniProtKB
  • steroid hormone receptor activity : IEA:InterPro
  • transcription corepressor activity : TAS:ProtInc
  • zinc ion binding : IEA:InterPro
GO - Biological process
  • anterior/posterior pattern specification : IEA:Ensembl
  • blood vessel morphogenesis : IEA:Ensembl
  • fertilization : IEA:Ensembl
  • forebrain development : IEA:Ensembl
  • limb development : IEA:Ensembl
  • lipid metabolic process : TAS:ProtInc
  • maternal placenta development : IEA:Ensembl
  • negative regulation of cyclin-dependent protein serine/threonine kinase activity : IDA:BHF-UCL
  • negative regulation of endothelial cell migration : IMP:BHF-UCL
  • negative regulation of endothelial cell proliferation : IMP:BHF-UCL
  • negative regulation of transcription by RNA polymerase II : IDA:UniProtKB
  • negative regulation of transcription, DNA-templated : IDA:BHF-UCL
  • neuron migration : IEA:Ensembl
  • placenta blood vessel development : IEA:Ensembl
  • positive regulation of systemic arterial blood pressure : IEA:Ensembl
  • positive regulation of transcription, DNA-templated : IDA:UniProtKB
  • radial pattern formation : IEA:Ensembl
  • regulation of transcription by RNA polymerase II : TAS:ProtInc
  • regulation of transcription involved in lymphatic endothelial cell fate commitment : IMP:BHF-UCL
  • response to estradiol : IEA:Ensembl
  • signal transduction : TAS:ProtInc
  • skeletal muscle tissue development : IEA:Ensembl
  • transcription, DNA-templated : IEA:UniProtKB-KW
  • trophoblast giant cell differentiation : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.