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P24386

Rab proteins geranylgeranyltransferase component A 1 (P24386)

Uniprot ID P24386
Protein Name Rab proteins geranylgeranyltransferase component A 1
Gene Name CHM
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.669
Function Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation. .
GO - Molecular function
  • GDP-dissociation inhibitor activity : IEA:InterPro
  • GTPase activator activity : IEA:UniProtKB-KW
  • Rab geranylgeranyltransferase activity : TAS:ProtInc
  • Rab GTPase binding : IDA:UniProtKB
GO - Biological process
  • post-translational protein modification : TAS:Reactome
  • protein geranylgeranylation : IDA:UniProtKB
  • protein targeting to membrane : IMP:UniProtKB
  • regulation of apoptotic process : TAS:Reactome
  • small GTPase mediated signal transduction : IEA:InterPro
  • vesicle-mediated transport : IBA:GO_Central
  • visual perception : TAS:ProtInc
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.