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P23528

Cofilin-1 (P23528)

Uniprot ID P23528
Protein Name Cofilin-1
Gene Name CFL1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.86
Function Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:11812157, PubMed:15580268, PubMed:21834987, PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity). .
GO - Molecular function
  • actin filament binding : IDA:UniProtKB
  • signaling receptor binding : IEA:Ensembl
GO - Biological process
  • actin cytoskeleton organization : TAS:ProtInc
  • actin filament depolymerization : IDA:UniProtKB
  • actin filament fragmentation : IEA:Ensembl
  • cytoskeleton organization : IMP:UniProtKB
  • establishment of cell polarity : IEA:Ensembl
  • interleukin-12-mediated signaling pathway : TAS:Reactome
  • mitotic cytokinesis : IEA:Ensembl
  • negative regulation of apoptotic process : TAS:UniProtKB
  • neural crest cell migration : IEA:Ensembl
  • neural fold formation : IEA:Ensembl
  • positive regulation by host of viral process : IMP:AgBase
  • positive regulation of actin filament depolymerization : IEA:Ensembl
  • protein phosphorylation : IEA:Ensembl
  • regulation of cell morphogenesis : IMP:UniProtKB
  • regulation of dendritic spine morphogenesis : IMP:ParkinsonsUK-UCL
  • response to amino acid : IEA:Ensembl
  • response to virus : IEP:UniProtKB
  • Rho protein signal transduction : TAS:ProtInc
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.