Purine nucleoside phosphorylase (P23492)

Uniprot ID P23492
Protein Name Purine nucleoside phosphorylase
Gene Name Pnp
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.0
Function The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. .
GO - Molecular function
  • drug binding : ISO:MGI
  • nucleoside binding : ISO:MGI
  • phosphate ion binding : ISO:MGI
  • purine nucleobase binding : ISO:MGI
  • purine-nucleoside phosphorylase activity : IDA:MGI
GO - Biological process
  • apoptotic mitochondrial changes : IMP:MGI
  • deoxyguanosine catabolic process : IMP:MGI
  • deoxyinosine catabolic process : IMP:MGI
  • dGTP metabolic process : IMP:MGI
  • GTP biosynthetic process : IMP:MGI
  • guanosine catabolic process : IMP:MGI
  • inosine catabolic process : IMP:MGI
  • intrinsic apoptotic signaling pathway in response to DNA damage : IMP:MGI
  • negative regulation of T cell apoptotic process : IMP:MGI
  • positive regulation of alpha-beta T cell differentiation : IMP:MGI
  • positive regulation of B cell differentiation : IMP:MGI
  • positive regulation of DNA repair : IMP:MGI
  • positive regulation of T cell mediated cytotoxicity : IMP:MGI
  • positive regulation of T cell proliferation : IMP:MGI
  • purine nucleoside metabolic process : IDA:MGI
  • response to gamma radiation : IMP:MGI
  • urate biosynthetic process : IMP:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.