Home Proteins Experiments Diseases Interactions Tutorial
Home
/
Proteins
/
P23471

Receptor-type tyrosine-protein phosphatase zeta (P23471)

Uniprot ID P23471
Protein Name Receptor-type tyrosine-protein phosphatase zeta
Gene Name PTPRZ1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.34
Function Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity). .
GO - Molecular function
  • protein tyrosine phosphatase activity : ISS:UniProtKB
  • transmembrane receptor protein tyrosine phosphatase activity : TAS:ProtInc
GO - Biological process
  • axonogenesis : IEA:Ensembl
  • central nervous system development : TAS:ProtInc
  • cytokine-mediated signaling pathway : TAS:Reactome
  • hematopoietic progenitor cell differentiation : IEA:Ensembl
  • learning or memory : ISS:UniProtKB
  • oligodendrocyte differentiation : ISS:UniProtKB
  • peptidyl-tyrosine dephosphorylation : ISS:UniProtKB
  • protein dephosphorylation : TAS:ProtInc
  • regulation of oligodendrocyte progenitor proliferation : ISS:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.