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P23249

Putative helicase MOV-10 (P23249)

Uniprot ID P23249
Protein Name Putative helicase MOV-10
Gene Name Mov10
Species Mus musculus (Mouse)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.305
Function Probable RNA helicase. Required for miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (By similarity). .
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • helicase activity : IEA:UniProtKB-KW
  • RNA binding : IEA:UniProtKB-KW
GO - Biological process
  • gene silencing by miRNA : ISS:UniProtKB
  • mRNA cleavage involved in gene silencing by miRNA : ISS:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.