| Signal peptide(a) |
N |
Secretome P(b) |
0.642 |
| Function |
Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP. . |
| GO - Molecular function |
- calcium ion binding : IDA:UniProtKB
- extracellular matrix structural constituent : IDA:UniProtKB
- fibrinogen binding : IPI:UniProtKB
- fibronectin binding : IPI:UniProtKB
- identical protein binding : IDA:UniProtKB
- integrin binding : IDA:UniProtKB
- peptidase activator activity : IEA:Ensembl
- protein C-terminus binding : IPI:UniProtKB
- protein-containing complex binding : IPI:UniProtKB
|
| GO - Biological process |
- blood coagulation, fibrin clot formation : IDA:UniProtKB
- embryo implantation : IEA:Ensembl
- extracellular matrix organization : IEA:Ensembl
- negative regulation of cell adhesion : IDA:UniProtKB
- negative regulation of cell motility : IDA:UniProtKB
- negative regulation of ERK1 and ERK2 cascade : IDA:UniProtKB
- negative regulation of protein phosphorylation : IDA:UniProtKB
- negative regulation of stem cell proliferation : IDA:UniProtKB
- negative regulation of substrate adhesion-dependent cell spreading : IDA:UniProtKB
- negative regulation of transformation of host cell by virus : IMP:UniProtKB
- negative regulation of transforming growth factor-beta secretion : IDA:UniProtKB
- positive regulation of fibroblast proliferation : IDA:UniProtKB
- positive regulation of gene expression : IDA:UniProtKB
- positive regulation of substrate-dependent cell migration, cell attachment to substrate : IDA:UniProtKB
- viral process : IEA:UniProtKB-KW
|