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P22692

Insulin-like growth factor-binding protein 4 (P22692)

Uniprot ID P22692
Protein Name Insulin-like growth factor-binding protein 4
Gene Name IGFBP4
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.903
Function IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
GO - Molecular function
  • insulin-like growth factor I binding : IBA:GO_Central
  • insulin-like growth factor II binding : IBA:GO_Central
  • signaling receptor binding : TAS:ParkinsonsUK-UCL
GO - Biological process
  • cell proliferation : TAS:ProtInc
  • cellular protein metabolic process : TAS:Reactome
  • DNA metabolic process : TAS:ProtInc
  • inflammatory response : IEA:Ensembl
  • negative regulation of canonical Wnt signaling pathway : TAS:ParkinsonsUK-UCL
  • positive regulation of insulin-like growth factor receptor signaling pathway : IEA:Ensembl
  • positive regulation of MAPK cascade : IEA:Ensembl
  • post-translational protein modification : TAS:Reactome
  • regulation of cell growth : IEA:Ensembl
  • regulation of glucose metabolic process : IEA:Ensembl
  • regulation of insulin-like growth factor receptor signaling pathway : IBA:GO_Central
  • signal transduction : TAS:ProtInc
  • skeletal system development : TAS:ProtInc
  • type B pancreatic cell proliferation : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.