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P22307

Non-specific lipid-transfer protein (P22307)

Uniprot ID P22307
Protein Name Non-specific lipid-transfer protein
Gene Name SCP2
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.606
Function Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis. .
GO - Molecular function
  • cholesterol binding : IDA:UniProtKB
  • fatty-acyl-CoA binding : IDA:UniProtKB
  • long-chain fatty acyl-CoA binding : IDA:UniProtKB
  • oleic acid binding : IDA:UniProtKB
  • phosphatidylinositol transporter activity : IDA:UniProtKB
  • propanoyl-CoA C-acyltransferase activity : IEA:UniProtKB-EC
  • propionyl-CoA C2-trimethyltridecanoyltransferase activity : EXP:Reactome
  • signaling receptor binding : IPI:UniProtKB
  • sterol transporter activity : IBA:GO_Central
GO - Biological process
  • alpha-linolenic acid metabolic process : TAS:Reactome
  • bile acid biosynthetic process : TAS:Reactome
  • fatty acid beta-oxidation using acyl-CoA oxidase : TAS:Reactome
  • inositol trisphosphate biosynthetic process : IDA:UniProtKB
  • lipid hydroperoxide transport : IDA:UniProtKB
  • phospholipid transport : IDA:UniProtKB
  • positive regulation of intracellular cholesterol transport : IDA:UniProtKB
  • positive regulation of steroid metabolic process : IDA:UniProtKB
  • progesterone biosynthetic process : IDA:UniProtKB
  • protein localization to plasma membrane : IDA:UniProtKB
  • protein targeting to peroxisome : TAS:Reactome
  • steroid biosynthetic process : IDA:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.