| Signal peptide(a) |
N |
Secretome P(b) |
0.096 |
| Function |
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). . |
| GO - Molecular function |
- ATP binding : IEA:UniProtKB-KW
- growth factor binding : IPI:BHF-UCL
- identical protein binding : IPI:IntAct
- neuregulin binding : IDA:UniProtKB
- neuregulin receptor activity : IBA:GO_Central
- protein heterodimerization activity : IDA:UniProtKB
- protein homodimerization activity : NAS:BHF-UCL
- protein tyrosine kinase activator activity : IDA:BHF-UCL
- transmembrane receptor protein tyrosine kinase activity : IBA:GO_Central
- transmembrane signaling receptor activity : ISS:BHF-UCL
- ubiquitin protein ligase binding : IPI:CAFA
|
| GO - Biological process |
- cranial nerve development : ISS:BHF-UCL
- endocardial cushion development : IEA:Ensembl
- ERBB2 signaling pathway : TAS:Reactome
- extrinsic apoptotic signaling pathway in absence of ligand : IMP:BHF-UCL
- heart development : ISS:BHF-UCL
- MAPK cascade : TAS:Reactome
- negative regulation of cell adhesion : IDA:BHF-UCL
- negative regulation of neuron apoptotic process : ISS:BHF-UCL
- negative regulation of secretion : IDA:BHF-UCL
- negative regulation of signal transduction : IDA:BHF-UCL
- nervous system development : IBA:GO_Central
- neuron apoptotic process : IMP:BHF-UCL
- peripheral nervous system development : ISS:BHF-UCL
- phosphatidylinositol 3-kinase signaling : IDA:BHF-UCL
- positive regulation of calcineurin-NFAT signaling cascade : IEA:Ensembl
- positive regulation of cardiac muscle tissue development : IEA:Ensembl
- positive regulation of cell population proliferation : IBA:GO_Central
- positive regulation of gene expression : IEA:Ensembl
- positive regulation of phosphatidylinositol 3-kinase signaling : TAS:BHF-UCL
- positive regulation of protein kinase B signaling : TAS:Reactome
- positive regulation of protein tyrosine kinase activity : IMP:BHF-UCL
- regulation of cell motility : TAS:Reactome
- regulation of cell population proliferation : IDA:BHF-UCL
- Schwann cell differentiation : ISS:BHF-UCL
- signal transduction : IDA:UniProtKB
- transmembrane receptor protein tyrosine kinase signaling pathway : ISS:BHF-UCL
- wound healing : NAS:BHF-UCL
|