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P21661

Neuroendocrine convertase 2 (P21661)

Uniprot ID P21661
Protein Name Neuroendocrine convertase 2
Gene Name Pcsk2
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (3) Interactions
Signal peptide(a) Y Secretome P(b) 0.426
Function Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity). .
GO - Molecular function
  • endopeptidase activity : IDA:BHF-UCL
  • protein-containing complex binding : ISO:MGI
  • serine-type endopeptidase activity : IDA:BHF-UCL
GO - Biological process
  • enkephalin processing : IDA:BHF-UCL
  • insulin processing : ISO:MGI
  • islet amyloid polypeptide processing : ISO:MGI
  • nervous system development : IEP:HGNC
  • peptide hormone processing : IDA:BHF-UCL
  • protein autoprocessing : IDA:HGNC
  • protein processing : IDA:BHF-UCL
  • proteolysis : IMP:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.