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P21583

Kit ligand (P21583)

Uniprot ID P21583
Protein Name Kit ligand
Gene Name KITLG
Species Homo sapiens (Human)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.182
Function Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
GO - Molecular function
  • cytokine activity : IBA:GO_Central
  • growth factor activity : IEA:UniProtKB-KW
  • stem cell factor receptor binding : IBA:GO_Central
GO - Biological process
  • cell adhesion : IEA:UniProtKB-KW
  • ectopic germ cell programmed cell death : IEA:Ensembl
  • embryonic hemopoiesis : IDA:DFLAT
  • extrinsic apoptotic signaling pathway in absence of ligand : IEA:Ensembl
  • male gonad development : IEP:UniProtKB
  • MAPK cascade : TAS:Reactome
  • negative regulation of mast cell apoptotic process : IEA:Ensembl
  • neural crest cell migration : IEA:Ensembl
  • ovarian follicle development : IEA:Ensembl
  • positive regulation of cell population proliferation : IDA:BHF-UCL
  • positive regulation of hematopoietic progenitor cell differentiation : TAS:GO_Central
  • positive regulation of hematopoietic stem cell proliferation : IEA:Ensembl
  • positive regulation of leukocyte migration : IEA:Ensembl
  • positive regulation of MAP kinase activity : IEA:Ensembl
  • positive regulation of mast cell proliferation : IEA:Ensembl
  • positive regulation of melanocyte differentiation : IEA:Ensembl
  • positive regulation of myeloid leukocyte differentiation : IEA:Ensembl
  • positive regulation of peptidyl-tyrosine phosphorylation : IEA:Ensembl
  • positive regulation of protein kinase B signaling : TAS:Reactome
  • positive regulation of Ras protein signal transduction : IEA:Ensembl
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.