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P20065

Thymosin beta-4 (P20065)

Uniprot ID P20065
Protein Name Thymosin beta-4
Gene Name Tmsb4x
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.75
Function Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase. .
GO - Molecular function
  • actin monomer binding : IEA:InterPro
GO - Biological process
  • actin filament organization : IEA:InterPro
  • osteoblast differentiation : IEA:Ensembl
  • positive regulation of smooth muscle cell differentiation : TAS:DFLAT
  • positive regulation of smooth muscle cell migration : TAS:DFLAT
  • positive regulation of transcription, DNA-templated : TAS:DFLAT
  • regulation of cell migration : IDA:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.