Beta-hexosaminidase subunit beta (P20060)

Uniprot ID P20060
Protein Name Beta-hexosaminidase subunit beta
Gene Name Hexb
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.651
Function Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues.
GO - Molecular function
  • acetylglucosaminyltransferase activity : ISO:MGI
  • beta-N-acetylglucosaminidase activity : ISO:MGI
  • beta-N-acetylhexosaminidase activity : IDA:MGI
  • carbohydrate binding : ISO:MGI
  • hexosaminidase activity : ISO:MGI
  • hydrolase activity : IDA:MGI
  • N-acetyl-beta-D-galactosaminidase activity : IEA:UniProtKB-EC
  • protein heterodimerization activity : ISO:MGI
  • protein homodimerization activity : IDA:MGI
GO - Biological process
  • astrocyte cell migration : IMP:UniProtKB
  • cellular calcium ion homeostasis : IMP:MGI
  • cellular protein metabolic process : IMP:MGI
  • ganglioside catabolic process : IMP:MGI
  • glycosaminoglycan metabolic process : IGI:MGI
  • glycosphingolipid metabolic process : IMP:MGI
  • lipid storage : IMP:MGI
  • locomotory behavior : IMP:MGI
  • lysosome organization : IMP:MGI
  • male courtship behavior : IMP:MGI
  • myelination : IGI:MGI
  • N-acetylglucosamine metabolic process : ISO:MGI
  • neuromuscular process : IMP:MGI
  • neuromuscular process controlling balance : IMP:MGI
  • oligosaccharide catabolic process : IMP:MGI
  • oogenesis : IMP:MGI
  • penetration of zona pellucida : IMP:MGI
  • phospholipid biosynthetic process : IMP:MGI
  • positive regulation of transcription by RNA polymerase II : IMP:UniProtKB
  • regulation of cell shape : IMP:UniProtKB
  • regulation of cellular metabolic process : IMP:MGI
  • sensory perception of sound : IGI:MGI
  • sexual reproduction : IMP:MGI
  • single fertilization : IMP:MGI
  • skeletal system development : IGI:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.