Protein CYR61 (P18406)

Uniprot ID	P18406
Protein Name	Protein CYR61
Gene Name	Cyr61
Species	Mus musculus (Mouse)

Signal peptide^(a)	Y	Secretome P^(b)	0.814
Function	Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CYR61-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3 (By similarity). .
GO - Molecular function	extracellular matrix binding : IDA:MGI heparin binding : IBA:GO_Central insulin-like growth factor binding : IEA:InterPro integrin binding : IDA:MGI
GO - Biological process	apoptotic process involved in heart morphogenesis : IMP:MGI atrial septum morphogenesis : IMP:MGI atrioventricular valve morphogenesis : IMP:MGI cell adhesion : IDA:MGI cell-cell adhesion : IDA:MGI cell-cell signaling : IBA:GO_Central chemotaxis : ISO:MGI chondroblast differentiation : IDA:MGI chorio-allantoic fusion : IMP:MGI extracellular matrix organization : IDA:MGI intussusceptive angiogenesis : IMP:MGI labyrinthine layer blood vessel development : IMP:MGI negative regulation of apoptotic process : IMP:MGI osteoblast differentiation : IGI:MGI positive regulation of apoptotic process : IGI:MGI positive regulation of BMP signaling pathway : ISO:MGI positive regulation of cartilage development : IMP:MGI positive regulation of cell differentiation : IDA:MGI positive regulation of cell migration : IDA:MGI positive regulation of cell-substrate adhesion : IDA:MGI positive regulation of ceramide biosynthetic process : IDA:MGI positive regulation of cysteine-type endopeptidase activity involved in apoptotic process : IGI:MGI positive regulation of osteoblast differentiation : ISO:MGI positive regulation of osteoblast proliferation : ISO:MGI positive regulation of phospholipase activity : IDA:MGI positive regulation of protein kinase activity : ISO:MGI positive regulation of protein phosphorylation : ISO:MGI positive regulation of transcription by RNA polymerase II : ISO:MGI reactive oxygen species metabolic process : IDA:MGI regulation of cell growth : IEA:InterPro regulation of ERK1 and ERK2 cascade : ISO:MGI signal transduction : IBA:GO_Central ventricular septum development : IMP:MGI wound healing, spreading of cells : ISO:MGI

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}