Glucosylceramidase (P17439)

Uniprot ID P17439
Protein Name Glucosylceramidase
Gene Name Gba
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.67
Function
GO - Molecular function
  • glucosylceramidase activity : IMP:ParkinsonsUK-UCL
  • hydrolase activity : IDA:MGI
  • scavenger receptor binding : ISO:MGI
  • signaling receptor binding : IPI:BHF-UCL
GO - Biological process
  • autophagosome organization : IMP:ParkinsonsUK-UCL
  • beta-glucoside catabolic process : ISO:MGI
  • cellular response to starvation : IMP:ParkinsonsUK-UCL
  • cellular response to tumor necrosis factor : ISO:MGI
  • ceramide biosynthetic process : ISO:MGI
  • glucosylceramide catabolic process : IMP:ParkinsonsUK-UCL
  • negative regulation of cellular protein metabolic process : IMP:ParkinsonsUK-UCL
  • negative regulation of interleukin-6 production : ISO:MGI
  • negative regulation of MAP kinase activity : ISO:MGI
  • negative regulation of neuron death : ISO:MGI
  • negative regulation of protein homooligomerization : IMP:ParkinsonsUK-UCL
  • positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization : IMP:ParkinsonsUK-UCL
  • positive regulation of neuronal action potential : ISO:MGI
  • positive regulation of proteasomal ubiquitin-dependent protein catabolic process : IMP:ParkinsonsUK-UCL
  • positive regulation of protein complex disassembly : ISO:MGI
  • positive regulation of protein dephosphorylation : ISO:MGI
  • positive regulation of protein lipidation : ISO:MGI
  • positive regulation of protein metabolic process : ISO:MGI
  • positive regulation of proteolysis involved in cellular protein catabolic process : IMP:ParkinsonsUK-UCL
  • regulation of cellular protein metabolic process : ISO:MGI
  • regulation of protein metabolic process : IMP:ParkinsonsUK-UCL
  • regulation of water loss via skin : ISO:MGI
  • response to dexamethasone : ISO:MGI
  • response to estrogen : ISO:MGI
  • response to pH : ISO:MGI
  • response to testosterone : ISO:MGI
  • response to thyroid hormone : ISO:MGI
  • skin morphogenesis : ISO:MGI
  • sphingosine biosynthetic process : ISO:MGI
  • termination of signal transduction : ISO:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.