| Signal peptide(a) |
Y |
Secretome P(b) |
0.674 |
| Function |
Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity). .The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. |
| GO - Molecular function |
- growth factor binding : ISO:MGI
- growth hormone receptor activity : IDA:MGI
- identical protein binding : ISO:MGI
- peptide hormone binding : IPI:MGI
- protein homodimerization activity : ISO:MGI
- protein kinase binding : ISO:MGI
- protein phosphatase binding : ISO:MGI
- SH2 domain binding : ISO:MGI
|
| GO - Biological process |
- 2-oxoglutarate metabolic process : IMP:BHF-UCL
- activation of Janus kinase activity : ISO:MGI
- activation of MAPK activity : ISO:MGI
- allantoin metabolic process : IMP:BHF-UCL
- cellular response to hormone stimulus : ISO:MGI
- citrate metabolic process : IMP:BHF-UCL
- creatine metabolic process : IMP:BHF-UCL
- creatinine metabolic process : IMP:BHF-UCL
- endocytosis : IEA:UniProtKB-KW
- fatty acid metabolic process : IMP:BHF-UCL
- growth hormone receptor signaling pathway : IDA:BHF-UCL
- hormone metabolic process : ISO:MGI
- hormone-mediated signaling pathway : ISO:MGI
- insulin-like growth factor receptor signaling pathway : ISO:MGI
- isoleucine metabolic process : IMP:BHF-UCL
- JAK-STAT cascade : ISO:MGI
- negative regulation of neuron death : ISO:MGI
- oxaloacetate metabolic process : IMP:BHF-UCL
- positive regulation of JAK-STAT cascade : ISO:MGI
- positive regulation of multicellular organism growth : ISO:MGI
- positive regulation of peptidyl-tyrosine phosphorylation : IDA:BHF-UCL
- regulation of multicellular organism growth : IDA:BHF-UCL
- response to estradiol : ISO:MGI
- succinate metabolic process : IMP:BHF-UCL
- taurine metabolic process : IMP:BHF-UCL
- valine metabolic process : IMP:BHF-UCL
|