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P16675

Lysosomal protective protein (P16675)

Uniprot ID P16675
Protein Name Lysosomal protective protein
Gene Name Ctsa
Species Mus musculus (Mouse)
Basic Information Experiments (5) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.787
Function Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.
GO - Molecular function
  • serine-type carboxypeptidase activity : ISS:ParkinsonsUK-UCL
GO - Biological process
  • negative regulation of chaperone-mediated autophagy : IMP:ParkinsonsUK-UCL
  • proteolysis : ISS:ParkinsonsUK-UCL
  • proteolysis involved in cellular protein catabolic process : IBA:GO_Central
  • regulation of protein stability : IMP:ParkinsonsUK-UCL
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.