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P16254

Signal recognition particle 14 kDa protein (P16254)

Uniprot ID P16254
Protein Name Signal recognition particle 14 kDa protein
Gene Name Srp14
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.53
Function Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
GO - Molecular function
  • 7S RNA binding : IEA:InterPro
  • endoplasmic reticulum signal peptide binding : IEA:InterPro
GO - Biological process
  • protein targeting to ER : ISO:MGI
  • response to drug : ISO:MGI
  • SRP-dependent cotranslational protein targeting to membrane : IEA:InterPro
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.