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P16110

Galectin-3 (P16110)

Uniprot ID P16110
Protein Name Galectin-3
Gene Name Lgals3
Species Mus musculus (Mouse)
Basic Information Experiments (4) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.0
Function Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells (By similarity). .
GO - Molecular function
  • advanced glycation end-product receptor activity : ISO:MGI
  • chemoattractant activity : ISO:MGI
  • disaccharide binding : ISO:MGI
  • Fc-gamma receptor I complex binding : ISO:MGI
  • IgE binding : ISO:MGI
  • laminin binding : ISO:MGI
  • monosaccharide binding : ISO:MGI
GO - Biological process
  • cell differentiation : IEA:UniProtKB-KW
  • eosinophil chemotaxis : ISO:MGI
  • extracellular matrix organization : IGI:MGI
  • innate immune response : IEA:UniProtKB-KW
  • macrophage chemotaxis : ISO:MGI
  • monocyte chemotaxis : ISO:MGI
  • mononuclear cell migration : ISO:MGI
  • mRNA processing : IEA:UniProtKB-KW
  • negative regulation of apoptotic process : ISO:MGI
  • negative regulation of cell proliferation in bone marrow : ISO:MGI
  • negative regulation of endocytosis : IMP:BHF-UCL
  • negative regulation of extrinsic apoptotic signaling pathway : ISO:MGI
  • negative regulation of immunological synapse formation : IMP:BHF-UCL
  • negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell : IMP:BHF-UCL
  • negative regulation of T cell receptor signaling pathway : IMP:BHF-UCL
  • neutrophil chemotaxis : ISO:MGI
  • positive chemotaxis : ISO:MGI
  • positive regulation of angiogenesis : ISO:MGI
  • positive regulation of calcium ion import : ISO:MGI
  • positive regulation of cell proliferation : ISO:MGI
  • positive regulation of mononuclear cell migration : ISO:MGI
  • positive regulation of serotonin secretion : ISO:MGI
  • regulation of extrinsic apoptotic signaling pathway via death domain receptors : ISO:MGI
  • regulation of T cell apoptotic process : ISO:MGI
  • regulation of T cell proliferation : ISO:MGI
  • RNA splicing : IEA:UniProtKB-KW
  • skeletal system development : IGI:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.