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P15864

Histone H1.2 (P15864)

Uniprot ID P15864
Protein Name Histone H1.2
Gene Name Hist1h1c
Species Mus musculus (Mouse)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.359
Function Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). .
GO - Molecular function
  • chromatin DNA binding : ISO:MGI
  • DNA binding : IDA:MGI
GO - Biological process
  • histone H3-K27 trimethylation : IGI:MGI
  • histone H3-K4 trimethylation : IGI:MGI
  • negative regulation of transcription by RNA polymerase II : IGI:MGI
  • nucleosome assembly : IEA:InterPro
  • nucleosome positioning : IMP:MGI
  • regulation of transcription by RNA polymerase II : IMP:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.