Beta-1,4-galactosyltransferase 1 (P15535)

Uniprot ID P15535
Protein Name Beta-1,4-galactosyltransferase 1
Gene Name B4galt1
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.641
Function The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix.
GO - Molecular function
  • alpha-tubulin binding : ISO:MGI
  • beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity : IDA:MGI
  • beta-tubulin binding : ISO:MGI
  • cytoskeletal protein binding : IDA:MGI
  • galactosyltransferase activity : IDA:MGI
  • lactose synthase activity : ISO:MGI
  • manganese ion binding : ISS:UniProtKB
  • N-acetyllactosamine synthase activity : ISO:MGI
  • protein homodimerization activity : ISO:MGI
  • protein kinase binding : ISO:MGI
  • UDP-galactosyltransferase activity : ISO:MGI
GO - Biological process
  • acute inflammatory response : IMP:MGI
  • angiogenesis involved in wound healing : IMP:MGI
  • binding of sperm to zona pellucida : IMP:MGI
  • branching morphogenesis of an epithelial tube : IMP:MGI
  • cell adhesion : IGI:MGI
  • development of secondary sexual characteristics : IMP:MGI
  • epithelial cell development : IMP:MGI
  • extracellular matrix organization : IMP:MGI
  • galactose metabolic process : IDA:MGI
  • glycoprotein biosynthetic process : IMP:MGI
  • lactose biosynthetic process : IMP:MGI
  • leukocyte migration : IMP:MGI
  • mammary gland development : IMP:MGI
  • negative regulation of cell proliferation : IMP:MGI
  • oligosaccharide biosynthetic process : IDA:MGI
  • penetration of zona pellucida : IMP:MGI
  • positive regulation of apoptotic process : IMP:MGI
  • positive regulation of apoptotic process involved in mammary gland involution : IMP:MGI
  • positive regulation of epithelial cell proliferation involved in wound healing : IMP:MGI
  • protein glycosylation : IMP:MGI
  • protein homooligomerization : ISO:MGI
  • protein N-linked glycosylation : ISS:UniProtKB
  • regulation of acrosome reaction : IMP:MGI
  • regulation of cell proliferation : IMP:MGI
  • regulation of cellular component movement : IDA:MGI
  • wound healing : IMP:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.