CD44 antigen (P15379)

Uniprot ID	P15379
Protein Name	CD44 antigen
Gene Name	Cd44
Species	Mus musculus (Mouse)

Signal peptide^(a)	Y	Secretome P^(b)	0.0
Function	Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis (By similarity). Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (PubMed:25065622). .
GO - Molecular function	epidermal growth factor receptor binding : ISO:MGI hyaluronic acid binding : IDA:MGI phosphoprotein binding : ISO:MGI protein kinase binding : ISO:MGI type II transforming growth factor beta receptor binding : IPI:UniProtKB
GO - Biological process	branching involved in prostate gland morphogenesis : IMP:MGI branching involved in ureteric bud morphogenesis : IMP:MGI cell adhesion : IDA:MGI cell migration : ISO:MGI cellular response to fibroblast growth factor stimulus : ISO:MGI cytokine-mediated signaling pathway : IEA:GOC hyaluronan catabolic process : ISO:MGI macrophage fusion : ISO:MGI monocyte aggregation : ISO:MGI negative regulation of apoptotic process : ISO:MGI negative regulation of CD4-positive, alpha-beta T cell proliferation : IMP:UniProtKB negative regulation of cysteine-type endopeptidase activity involved in apoptotic process : ISO:MGI negative regulation of DNA damage response, signal transduction by p53 class mediator : IMP:BHF-UCL negative regulation of inflammatory response : IMP:UniProtKB negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator : IMP:BHF-UCL negative regulation of mature B cell apoptotic process : IDA:BHF-UCL negative regulation of regulatory T cell differentiation : IMP:UniProtKB neuron projection development : ISO:MGI positive regulation of adaptive immune response : NAS:BHF-UCL positive regulation of ERK1 and ERK2 cascade : IMP:BHF-UCL positive regulation of gene expression : IMP:UniProtKB positive regulation of heterotypic cell-cell adhesion : ISO:MGI positive regulation of kinase activity : ISO:MGI positive regulation of monocyte aggregation : ISO:MGI positive regulation of neutrophil apoptotic process : ISO:MGI positive regulation of peptidyl-serine phosphorylation : IMP:BHF-UCL positive regulation of peptidyl-tyrosine phosphorylation : IMP:BHF-UCL regulation of cell growth : ISO:MGI regulation of lamellipodium morphogenesis : ISS:UniProtKB Wnt signaling pathway : IDA:MGI wound healing involved in inflammatory response : IMP:MGI wound healing, spreading of cells : ISS:UniProtKB

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}