| Signal peptide(a) |
Y |
Secretome P(b) |
0.106 |
| Function |
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence (PubMed:24952463). CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. . |
| GO - Molecular function |
- alpha-catenin binding : ISO:MGI
- beta-catenin binding : ISO:MGI
- calcium ion binding : IEA:InterPro
- enzyme binding : IPI:UniProtKB
- gamma-catenin binding : ISO:MGI
- identical protein binding : IPI:IntAct
- nitric-oxide synthase binding : ISO:MGI
- protein kinase binding : IPI:UniProtKB
- protein phosphatase binding : IPI:UniProtKB
- protein-containing complex binding : ISO:MGI
|
| GO - Biological process |
- blood vessel morphogenesis : IMP:MGI
- brain morphogenesis : IGI:MGI
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules : IDA:MGI
- cell adhesion : IDA:MGI
- cell migration : IDA:MGI
- cell-cell adhesion : ISO:MGI
- cell-cell adhesion mediated by cadherin : IDA:UniProtKB
- cerebral cortex development : IGI:MGI
- glial cell differentiation : IDA:UniProtKB
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules : IDA:MGI
- homeostasis of number of cells : IGI:MGI
- homophilic cell adhesion via plasma membrane adhesion molecules : IDA:MGI
- negative regulation of canonical Wnt signaling pathway : IGI:MGI
- neuroepithelial cell differentiation : IGI:MGI
- neuroligin clustering involved in postsynaptic membrane assembly : IMP:BHF-UCL
- neuronal stem cell population maintenance : IDA:UniProtKB
- positive regulation of MAPK cascade : IGI:MGI
- positive regulation of synaptic vesicle clustering : IMP:BHF-UCL
- protein heterooligomerization : ISO:MGI
- protein localization to plasma membrane : IDA:UniProtKB
- radial glial cell differentiation : IGI:MGI
- regulation of axonogenesis : ISO:MGI
- regulation of myelination : ISO:MGI
- regulation of oligodendrocyte progenitor proliferation : IGI:MGI
- regulation of postsynaptic density protein 95 clustering : IMP:BHF-UCL
- regulation of protein localization : ISO:MGI
- regulation of Rho protein signal transduction : ISO:MGI
- regulation of synaptic transmission, glutamatergic : ISO:MGI
- striated muscle cell differentiation : IGI:MGI
- synapse assembly : ISO:MGI
- telencephalon development : IGI:MGI
|