| Signal peptide(a) |
N |
Secretome P(b) |
0.693 |
| Function |
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. |
| GO - Molecular function |
- enzyme binding : ISO:MGI
- heme binding : ISO:MGI
- heme oxygenase (decyclizing) activity : ISO:MGI
- metal ion binding : IEA:UniProtKB-KW
- phospholipase D activity : ISO:MGI
- protein homodimerization activity : ISO:MGI
|
| GO - Biological process |
- angiogenesis : ISO:MGI
- cell death : ISO:MGI
- cellular iron ion homeostasis : ISO:MGI
- cellular response to arsenic-containing substance : IDA:MGI
- cellular response to cadmium ion : IDA:MGI
- cellular response to cisplatin : IMP:MGI
- cellular response to heat : ISO:MGI
- cellular response to hypoxia : IEA:Ensembl
- cellular response to nutrient : IEA:Ensembl
- erythrocyte homeostasis : ISO:MGI
- heme catabolic process : ISO:MGI
- heme metabolic process : IDA:MGI
- heme oxidation : ISO:MGI
- intracellular signal transduction : ISO:MGI
- intrinsic apoptotic signaling pathway in response to DNA damage : ISO:MGI
- iron ion homeostasis : ISO:MGI
- liver regeneration : ISO:MGI
- negative regulation of cell proliferation : ISO:MGI
- negative regulation of DNA binding : ISO:MGI
- negative regulation of DNA binding transcription factor activity : ISO:MGI
- negative regulation of epithelial cell apoptotic process : ISO:MGI
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors : ISO:MGI
- negative regulation of macroautophagy : IMP:MGI
- negative regulation of mast cell cytokine production : ISO:MGI
- negative regulation of mast cell degranulation : ISO:MGI
- negative regulation of muscle cell apoptotic process : ISO:MGI
- negative regulation of neuron apoptotic process : ISO:MGI
- negative regulation of smooth muscle cell proliferation : ISO:MGI
- negative regulation of vascular smooth muscle cell proliferation : ISO:MGI
- positive regulation of angiogenesis : ISO:MGI
- positive regulation of apoptotic process : IMP:MGI
- positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis : ISO:MGI
- positive regulation of cell migration involved in sprouting angiogenesis : ISO:MGI
- positive regulation of macroautophagy : IMP:MGI
- positive regulation of smooth muscle cell proliferation : ISO:MGI
- protein homooligomerization : ISO:MGI
- regulation of blood pressure : ISO:MGI
- regulation of DNA binding transcription factor activity : ISO:MGI
- regulation of transcription from RNA polymerase II promoter in response to iron : IDA:MGI
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress : ISO:MGI
- response to estrogen : ISO:MGI
- response to hydrogen peroxide : ISO:MGI
- response to hypoxia : ISO:MGI
- response to nicotine : ISO:MGI
- response to oxidative stress : ISO:MGI
- small GTPase mediated signal transduction : ISO:MGI
- wound healing involved in inflammatory response : ISO:MGI
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