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P14543

Nidogen-1 (P14543)

Uniprot ID P14543
Protein Name Nidogen-1
Gene Name NID1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.611
Function Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.
GO - Molecular function
  • calcium ion binding : IEA:InterPro
  • collagen binding : IDA:BHF-UCL
  • extracellular matrix structural constituent : ISS:BHF-UCL
  • laminin binding : IDA:BHF-UCL
  • laminin-1 binding : IEA:Ensembl
  • proteoglycan binding : IPI:BHF-UCL
  • Wnt-activated receptor activity : IBA:GO_Central
  • Wnt-protein binding : IBA:GO_Central
GO - Biological process
  • basement membrane organization : TAS:BHF-UCL
  • canonical Wnt signaling pathway : IBA:GO_Central
  • cell-matrix adhesion : IEA:Ensembl
  • extracellular matrix organization : TAS:Reactome
  • glomerular basement membrane development : IEA:Ensembl
  • positive regulation of cell-substrate adhesion : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.