Endothelin-3 (P14138)

Uniprot ID P14138
Protein Name Endothelin-3
Gene Name EDN3
Species Homo sapiens (Human)
Signal peptide(a) Y Secretome P(b) 0.959
Function Endothelins are endothelium-derived vasoconstrictor peptides.
GO - Molecular function
  • endothelin B receptor binding : IPI:BHF-UCL
  • hormone activity : IDA:BHF-UCL
  • signaling receptor binding : TAS:ProtInc
GO - Biological process
  • blood circulation : TAS:ProtInc
  • cell surface receptor signaling pathway : IDA:BHF-UCL
  • cell-cell signaling : TAS:ProtInc
  • cellular calcium ion homeostasis : IEA:Ensembl
  • cellular magnesium ion homeostasis : IEA:Ensembl
  • G protein-coupled receptor signaling pathway : TAS:Reactome
  • inositol phosphate-mediated signaling : IDA:BHF-UCL
  • melanocyte differentiation : IEA:Ensembl
  • multicellular organism development : TAS:ProtInc
  • neural crest cell migration : IEA:Ensembl
  • neuron differentiation : IEA:Ensembl
  • neutrophil chemotaxis : IDA:BHF-UCL
  • peptide hormone secretion : IDA:BHF-UCL
  • positive regulation of cell differentiation : IGI:MGI
  • positive regulation of cell population proliferation : IDA:MGI
  • positive regulation of heart rate : IDA:BHF-UCL
  • positive regulation of hormone secretion : IDA:BHF-UCL
  • positive regulation of leukocyte chemotaxis : IDA:BHF-UCL
  • positive regulation of MAP kinase activity : IDA:BHF-UCL
  • positive regulation of mitotic nuclear division : IDA:BHF-UCL
  • positive regulation of potassium ion transmembrane transport : IEA:Ensembl
  • regulation of developmental pigmentation : IEA:Ensembl
  • regulation of gene expression : IGI:MGI
  • regulation of systemic arterial blood pressure by endothelin : IDA:BHF-UCL
  • regulation of vasoconstriction : IEA:InterPro
  • signal transduction : TAS:ProtInc
  • vasoconstriction : IDA:BHF-UCL
  • vein smooth muscle contraction : IDA:BHF-UCL
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.