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P13497

Bone morphogenetic protein 1 (P13497)

Uniprot ID P13497
Protein Name Bone morphogenetic protein 1
Gene Name BMP1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.521
Function Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX.
GO - Molecular function
  • calcium ion binding : IEA:InterPro
  • cytokine activity : IEA:UniProtKB-KW
  • growth factor activity : IEA:UniProtKB-KW
  • identical protein binding : IPI:IntAct
  • metalloendopeptidase activity : IEA:Ensembl
  • metallopeptidase activity : NAS:UniProtKB
  • peptidase activity : IDA:UniProtKB
  • zinc ion binding : IEA:InterPro
GO - Biological process
  • cartilage condensation : TAS:ProtInc
  • cell differentiation : IEA:UniProtKB-KW
  • extracellular matrix disassembly : TAS:Reactome
  • high-density lipoprotein particle assembly : TAS:Reactome
  • multicellular organism development : TAS:ProtInc
  • ossification : IEA:UniProtKB-KW
  • positive regulation of cartilage development : IDA:MGI
  • proteolysis : IDA:UniProtKB
  • skeletal system development : TAS:ProtInc
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.