Interleukin-7 (P13232)

Uniprot ID P13232
Protein Name Interleukin-7
Gene Name IL7
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b) 0.935
Function Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.
GO - Molecular function
  • cytokine activity : IDA:UniProtKB
  • growth factor activity : ISS:UniProtKB
  • interleukin-7 receptor binding : TAS:ProtInc
GO - Biological process
  • animal organ morphogenesis : TAS:ProtInc
  • bone resorption : ISS:UniProtKB
  • cell-cell signaling : TAS:ProtInc
  • cytokine-mediated signaling pathway : IDA:UniProtKB
  • homeostasis of number of cells within a tissue : IEA:Ensembl
  • humoral immune response : TAS:ProtInc
  • interleukin-7-mediated signaling pathway : TAS:Reactome
  • negative regulation of apoptotic process : ISS:UniProtKB
  • negative regulation of catalytic activity : IEA:Ensembl
  • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand : IEA:Ensembl
  • positive regulation of B cell differentiation : IEA:Ensembl
  • positive regulation of B cell proliferation : ISS:UniProtKB
  • positive regulation of cell population proliferation : TAS:ProtInc
  • positive regulation of chemokine production : IDA:UniProtKB
  • positive regulation of cytokine-mediated signaling pathway : IDA:UniProtKB
  • positive regulation of gene expression : IEA:Ensembl
  • positive regulation of organ growth : IEA:Ensembl
  • positive regulation of T cell differentiation : ISS:UniProtKB
  • regulation of peptidyl-tyrosine phosphorylation : IEA:Ensembl
  • T cell lineage commitment : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.