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P12277

Creatine kinase B-type (P12277)

Uniprot ID P12277
Protein Name Creatine kinase B-type
Gene Name CKB
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.382
Function Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • creatine kinase activity : ISS:AgBase
  • kinase activity : IBA:GO_Central
  • ubiquitin protein ligase binding : IPI:ParkinsonsUK-UCL
GO - Biological process
  • cellular chloride ion homeostasis : IEA:Ensembl
  • cerebellum development : IEA:Ensembl
  • creatine metabolic process : TAS:Reactome
  • phosphocreatine biosynthetic process : IBA:GO_Central
  • substantia nigra development : HEP:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.