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P11980

Pyruvate kinase PKM (P11980)

Uniprot ID P11980
Protein Name Pyruvate kinase PKM
Gene Name Pkm
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (By similarity). Stimulates POU5F1-mediated transcriptional activation (By similarity). Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages (By similarity). .
GO - Molecular function
  • ADP binding : IDA:RGD
  • ATP binding : IEA:UniProtKB-KW
  • identical protein binding : IDA:CAFA
  • kinase activity : IEA:UniProtKB-KW
  • magnesium ion binding : IEA:InterPro
  • potassium ion binding : IEA:InterPro
  • pyruvate kinase activity : IDA:CAFA
  • thyroid hormone binding : IDA:CAFA
GO - Biological process
  • animal organ regeneration : IDA:RGD
  • ATP biosynthetic process : IDA:RGD
  • cellular response to insulin stimulus : IBA:GO_Central
  • glucose metabolic process : IDA:RGD
  • glycolytic process : IDA:CAFA
  • liver development : IDA:RGD
  • positive regulation of sprouting angiogenesis : ISS:UniProtKB
  • programmed cell death : ISO:RGD
  • pyruvate biosynthetic process : IDA:RGD
  • response to gravity : IEP:RGD
  • response to hypoxia : IEP:RGD
  • response to insulin : IEP:RGD
  • response to muscle inactivity : IEP:RGD
  • response to nutrient : IEP:RGD
  • response to organic substance : IEP:RGD
  • skeletal muscle tissue regeneration : IDA:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.