| Signal peptide(a) |
Y |
Secretome P(b) |
0.0 |
| Function |
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.[Angiotensin-2]: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. .[Angiotensin-3]: stimulates aldosterone release. {ECO:0000250}.[Angiotensin 1-7]: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets. |
| GO - Molecular function |
- hormone activity : ISO:MGI
- receptor ligand activity : ISO:MGI
- serine-type endopeptidase inhibitor activity : IBA:GO_Central
- sodium channel regulator activity : ISO:MGI
- type 1 angiotensin receptor binding : IDA:MGI
- type 2 angiotensin receptor binding : IPI:MGI
|
| GO - Biological process |
- activation of MAPK activity : ISO:MGI
- activation of NF-kappaB-inducing kinase activity : IDA:MGI
- activation of phospholipase C activity : ISO:MGI
- angiotensin-activated signaling pathway : ISO:MGI
- angiotensin-mediated drinking behavior : ISO:MGI
- angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure : IDA:MGI
- artery smooth muscle contraction : ISO:MGI
- associative learning : ISO:MGI
- astrocyte activation : IMP:MGI
- blood vessel development : IMP:MGI
- brain renin-angiotensin system : IDA:MGI
- branching involved in ureteric bud morphogenesis : IDA:MGI
- cell growth involved in cardiac muscle cell development : ISO:MGI
- cell surface receptor signaling pathway : ISO:MGI
- cell-matrix adhesion : IMP:MGI
- cellular sodium ion homeostasis : ISO:MGI
- cytokine secretion : ISO:MGI
- drinking behavior : IMP:MGI
- ERK1 and ERK2 cascade : ISO:MGI
- establishment of blood-nerve barrier : IMP:MGI
- excretion : IMP:MGI
- extracellular matrix organization : IMP:MGI
- fibroblast proliferation : ISO:MGI
- G protein-coupled receptor signaling pathway : ISO:MGI
- hormone metabolic process : IMP:MGI
- kidney development : IMP:MGI
- negative regulation of angiogenesis : ISO:MGI
- negative regulation of cell growth : ISO:MGI
- negative regulation of cell population proliferation : IMP:MGI
- negative regulation of endopeptidase activity : IBA:GO_Central
- negative regulation of gene expression : ISO:MGI
- negative regulation of MAP kinase activity : ISO:MGI
- negative regulation of neuron apoptotic process : IMP:MGI
- negative regulation of neurotrophin TRK receptor signaling pathway : ISO:MGI
- negative regulation of tissue remodeling : ISO:MGI
- operant conditioning : ISO:MGI
- ovarian follicle rupture : IMP:MGI
- peristalsis : IMP:MGI
- positive regulation of activation of Janus kinase activity : ISO:MGI
- positive regulation of blood pressure : ISO:MGI
- positive regulation of blood vessel diameter : ISO:MGI
- positive regulation of branching involved in ureteric bud morphogenesis : ISO:MGI
- positive regulation of cardiac muscle cell apoptotic process : ISO:MGI
- positive regulation of cardiac muscle hypertrophy : ISO:MGI
- positive regulation of catalytic activity : ISO:MGI
- positive regulation of cell population proliferation : ISO:MGI
- positive regulation of cellular protein metabolic process : ISO:MGI
- positive regulation of cholesterol esterification : ISO:MGI
- positive regulation of cytokine secretion : IMP:UniProtKB
- positive regulation of cytosolic calcium ion concentration : ISO:MGI
- positive regulation of endothelial cell migration : ISO:MGI
- positive regulation of epidermal growth factor receptor signaling pathway : ISO:MGI
- positive regulation of extracellular matrix constituent secretion : ISO:MGI
- positive regulation of extrinsic apoptotic signaling pathway : ISO:MGI
- positive regulation of fatty acid biosynthetic process : IMP:MGI
- positive regulation of fibroblast proliferation : ISO:MGI
- positive regulation of gap junction assembly : ISO:MGI
- positive regulation of gene expression : IDA:MGI
- positive regulation of insulin receptor signaling pathway : ISO:MGI
- positive regulation of L-arginine import across plasma membrane : ISO:MGI
- positive regulation of L-lysine import across plasma membrane : ISO:MGI
- positive regulation of MAPK cascade : IMP:MGI
- positive regulation of membrane hyperpolarization : ISO:MGI
- positive regulation of multicellular organism growth : IMP:MGI
- positive regulation of neuron projection development : ISO:MGI
- positive regulation of nitric oxide biosynthetic process : ISO:MGI
- positive regulation of organ growth : IDA:MGI
- positive regulation of peptidyl-serine phosphorylation : IDA:MGI
- positive regulation of peptidyl-tyrosine phosphorylation : ISO:MGI
- positive regulation of phosphatidylinositol 3-kinase signaling : ISO:MGI
- positive regulation of protein kinase C activity : IDA:MGI
- positive regulation of protein tyrosine kinase activity : ISO:MGI
- positive regulation of renal sodium excretion : ISO:MGI
- positive regulation of superoxide anion generation : ISO:MGI
- positive regulation of transcription, DNA-templated : ISO:MGI
- positive regulation of vascular associated smooth muscle cell migration : ISO:MGI
- positive regulation of vascular smooth muscle cell proliferation : ISO:MGI
- protein import into nucleus : ISO:MGI
- regulation of apoptotic process : IDA:MGI
- regulation of blood pressure : IMP:MGI
- regulation of calcium ion transport : ISO:MGI
- regulation of cardiac conduction : ISO:MGI
- regulation of extracellular matrix assembly : ISO:MGI
- regulation of gene expression : IDA:MGI
- regulation of heart rate : ISO:MGI
- regulation of inflammatory response : IDA:MGI
- regulation of long-term neuronal synaptic plasticity : ISO:MGI
- regulation of norepinephrine secretion : ISO:MGI
- regulation of renal output by angiotensin : IMP:MGI
- regulation of renal sodium excretion : ISO:MGI
- regulation of systemic arterial blood pressure by circulatory renin-angiotensin : IMP:MGI
- regulation of transmission of nerve impulse : ISO:MGI
- renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure : IMP:MGI
- renal system process : ISO:MGI
- renin-angiotensin regulation of aldosterone production : IMP:MGI
- response to cold : IMP:MGI
- response to muscle activity involved in regulation of muscle adaptation : ISO:MGI
- response to salt stress : IMP:MGI
- smooth muscle cell differentiation : IDA:MGI
- smooth muscle cell proliferation : IDA:MGI
- stress-activated MAPK cascade : ISO:MGI
- uterine smooth muscle contraction : ISO:MGI
- vasoconstriction : ISO:MGI
- vasodilation : ISO:MGI
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