| Signal peptide(a) |
Y |
Secretome P(b) |
0.0 |
| Function |
Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (By similarity). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (By similarity). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (By similarity). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (By similarity). Alpha-M/beta-2 play a critical role in mast cell development and in immune complex-mediated glomerulonephritis. Mice expressing a null mutation of the alpha-M subunit gene demonstrate increase in neutrophil accumulation, in response to a impaired degranulation and phagocytosis, events that apparently accelerate apoptosis in neutrophils. These mice develop obesity. . |
| GO - Molecular function |
- amyloid-beta binding : IMP:ARUK-UCL
- cell adhesion molecule binding : ISO:MGI
- complement component C3b binding : IGI:ARUK-UCL
- heat shock protein binding : ISO:MGI
- ICAM-3 receptor activity : ISO:MGI
- metal ion binding : IEA:UniProtKB-KW
- protein heterodimerization activity : ISO:MGI
- protein kinase binding : ISO:MGI
- protein-containing complex binding : ISO:MGI
|
| GO - Biological process |
- activated T cell proliferation : IMP:MGI
- amyloid-beta clearance : IMP:ARUK-UCL
- cell adhesion : IMP:MGI
- cell-cell adhesion : IGI:MGI
- cell-matrix adhesion : ISO:MGI
- cellular extravasation : IMP:MGI
- cellular response to low-density lipoprotein particle stimulus : IDA:UniProtKB
- endothelial cell migration : ISO:MGI
- heterotypic cell-cell adhesion : ISO:MGI
- integrin-mediated signaling pathway : IDA:MGI
- leukocyte cell-cell adhesion : ISO:MGI
- leukocyte migration involved in inflammatory response : ISO:MGI
- natural killer cell activation : ISO:MGI
- neutrophil chemotaxis : IMP:MGI
- neutrophil migration : ISO:MGI
- phagocytosis, engulfment : IMP:ARUK-UCL
- positive regulation of angiogenesis : ISO:MGI
- positive regulation of neutrophil degranulation : ISO:MGI
- positive regulation of NF-kappaB transcription factor activity : ISO:MGI
- positive regulation of nitric oxide biosynthetic process : ISO:MGI
- positive regulation of superoxide anion generation : ISO:MGI
- receptor clustering : ISO:MGI
- receptor internalization : IDA:UniProtKB
- regulation of peptidyl-tyrosine phosphorylation : ISO:MGI
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