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P11762

Galectin-1 (P11762)

Uniprot ID P11762
Protein Name Galectin-1
Gene Name Lgals1
Species Rattus norvegicus (Rat)
Basic Information Experiments (6) Disease (6) Interactions
Signal peptide(a) N Secretome P(b) 0.701
Function Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. .
GO - Molecular function
  • carbohydrate binding : ISO:RGD
  • identical protein binding : IPI:RGD
  • lactose binding : IDA:RGD
  • laminin binding : IDA:RGD
GO - Biological process
  • apoptotic process : IEA:UniProtKB-KW
  • cellular response to glucose stimulus : IEP:RGD
  • cellular response to organic cyclic compound : IEP:RGD
  • myoblast differentiation : ISO:RGD
  • negative regulation of cell-substrate adhesion : IDA:RGD
  • negative regulation of neuron projection development : IMP:RGD
  • plasma cell differentiation : ISO:RGD
  • positive regulation of erythrocyte aggregation : IDA:RGD
  • positive regulation of viral entry into host cell : ISO:RGD
  • response to axon injury : IEP:RGD
  • response to drug : IEP:RGD
  • response to isolation stress : IEP:RGD
  • T cell costimulation : ISO:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.