Interleukin-1 beta (P10749)

Uniprot ID	P10749
Protein Name	Interleukin-1 beta
Gene Name	Il1b
Species	Mus musculus (Mouse)

Signal peptide^(a)	N	Secretome P^(b)	0.875
Function	Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. .
GO - Molecular function	cytokine activity : IDA:MGI integrin binding : ISS:UniProtKB interleukin-1 receptor binding : IBA:GO_Central protein domain specific binding : ISO:MGI
GO - Biological process	activation of MAPK activity : ISO:MGI cellular response to antibiotic : IBA:GO_Central cellular response to drug : ISO:MGI cellular response to fatty acid : IBA:GO_Central cellular response to glucose stimulus : IBA:GO_Central cellular response to lipopolysaccharide : IBA:GO_Central cellular response to mechanical stimulus : IBA:GO_Central cellular response to organic cyclic compound : ISO:MGI cellular response to organic substance : ISO:MGI chronic inflammatory response to antigenic stimulus : IBA:GO_Central cytokine-mediated signaling pathway : ISO:MGI ectopic germ cell programmed cell death : IGI:MGI extrinsic apoptotic signaling pathway in absence of ligand : IMP:MGI fever generation : IBA:GO_Central hyaluronan biosynthetic process : ISO:MGI inflammatory response : ISO:MGI interleukin-1 beta production : IGI:MGI interleukin-6 production : IDA:MGI leukocyte migration : IDA:MGI lipopolysaccharide-mediated signaling pathway : ISO:MGI MAPK cascade : ISO:MGI memory : ISO:MGI monocyte aggregation : ISO:MGI negative regulation of adiponectin secretion : IDA:BHF-UCL negative regulation of branching morphogenesis of a nerve : ISO:MGI negative regulation of cell proliferation : ISO:MGI negative regulation of extrinsic apoptotic signaling pathway in absence of ligand : ISO:MGI negative regulation of gene expression : ISO:MGI negative regulation of glucose transmembrane transport : IDA:BHF-UCL negative regulation of glutamate secretion : ISO:MGI negative regulation of insulin receptor signaling pathway : IDA:BHF-UCL negative regulation of lipid catabolic process : ISO:MGI negative regulation of lipid metabolic process : IDA:BHF-UCL negative regulation of MAP kinase activity : IDA:BHF-UCL negative regulation of neural precursor cell proliferation : ISO:MGI negative regulation of neurogenesis : ISO:MGI negative regulation of neuron differentiation : ISO:MGI negative regulation of synaptic transmission : IMP:ARUK-UCL negative regulation of transcription by RNA polymerase II : ISO:MGI neutrophil chemotaxis : IDA:MGI ovulation : IBA:GO_Central positive regulation of angiogenesis : IMP:BHF-UCL positive regulation of apoptotic process : ISO:MGI positive regulation of astrocyte differentiation : ISO:MGI positive regulation of calcidiol 1-monooxygenase activity : ISO:MGI positive regulation of cell death : ISO:MGI positive regulation of cell division : IEA:UniProtKB-KW positive regulation of cell migration : ISO:MGI positive regulation of cell proliferation : ISO:MGI positive regulation of chemokine biosynthetic process : IDA:MGI positive regulation of cytosolic calcium ion concentration : ISO:MGI positive regulation of DNA-binding transcription factor activity : ISO:MGI positive regulation of epithelial to mesenchymal transition : ISO:MGI positive regulation of ERK1 and ERK2 cascade : ISO:MGI positive regulation of estradiol secretion : IBA:GO_Central positive regulation of fever generation : IDA:BHF-UCL positive regulation of gene expression : IDA:MGI positive regulation of glial cell differentiation : ISO:MGI positive regulation of glial cell proliferation : IEA:Ensembl positive regulation of granulocyte macrophage colony-stimulating factor production : ISO:MGI positive regulation of heterotypic cell-cell adhesion : ISO:MGI positive regulation of I-kappaB kinase/NF-kappaB signaling : IDA:MGI positive regulation of immature T cell proliferation in thymus : ISO:MGI positive regulation of interferon-gamma production : ISS:UniProtKB positive regulation of interleukin-2 biosynthetic process : ISO:MGI positive regulation of interleukin-6 biosynthetic process : IDA:MGI positive regulation of interleukin-6 production : IDA:MGI positive regulation of interleukin-6 secretion : IDA:UniProtKB positive regulation of interleukin-8 production : ISO:MGI positive regulation of JNK cascade : IDA:MGI positive regulation of JUN kinase activity : ISO:MGI positive regulation of lipid catabolic process : IDA:BHF-UCL positive regulation of membrane protein ectodomain proteolysis : ISO:MGI positive regulation of mitotic nuclear division : ISO:MGI positive regulation of monocyte chemotactic protein-1 production : ISO:MGI positive regulation of myosin light chain kinase activity : ISO:MGI positive regulation of neuron apoptotic process : ISO:MGI positive regulation of neutrophil chemotaxis : ISO:MGI positive regulation of NF-kappaB transcription factor activity : ISO:MGI positive regulation of NIK/NF-kappaB signaling : ISO:MGI positive regulation of nitric oxide biosynthetic process : ISO:MGI positive regulation of p38MAPK cascade : IGI:ARUK-UCL positive regulation of phagocytosis : ISO:MGI positive regulation of prostaglandin secretion : IDA:BHF-UCL positive regulation of protein phosphorylation : ISO:MGI positive regulation of stress-activated MAPK cascade : ISO:MGI positive regulation of T cell proliferation : ISO:MGI positive regulation of T-helper 1 cell cytokine production : ISS:UniProtKB positive regulation of transcription by RNA polymerase II : IDA:MGI positive regulation of transcription, DNA-templated : ISO:MGI positive regulation of vascular endothelial growth factor production : IMP:BHF-UCL protein kinase B signaling : ISO:MGI regulation of defense response to virus by host : IDA:CAFA regulation of ERK1 and ERK2 cascade : ISO:MGI regulation of establishment of endothelial barrier : ISO:MGI regulation of I-kappaB kinase/NF-kappaB signaling : ISO:MGI regulation of insulin secretion : ISO:MGI regulation of neurogenesis : ISO:MGI regulation of nitric-oxide synthase activity : IDA:UniProtKB response to ATP : IDA:MGI response to carbohydrate : IDA:MGI response to dexamethasone : IBA:GO_Central response to drug : IBA:GO_Central response to estradiol : IBA:GO_Central response to ethanol : IBA:GO_Central response to gamma radiation : IBA:GO_Central response to glucocorticoid : IBA:GO_Central response to heat : IBA:GO_Central response to hypoxia : IBA:GO_Central response to immobilization stress : IBA:GO_Central response to L-ascorbic acid : IBA:GO_Central response to lipopolysaccharide : IDA:MGI response to morphine : IBA:GO_Central response to organic cyclic compound : IBA:GO_Central response to ozone : IBA:GO_Central response to peptide hormone : IBA:GO_Central response to stilbenoid : IBA:GO_Central response to vitamin D : IBA:GO_Central sequestering of triglyceride : ISO:MGI social behavior : ISO:MGI wound healing : IBA:GO_Central

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}