Transforming growth factor beta-3 (P10600)

Uniprot ID P10600
Protein Name Transforming growth factor beta-3
Gene Name TGFB3
Species Homo sapiens (Human)
Signal peptide(a) Y Secretome P(b) 0.912
Function Involved in embryogenesis and cell differentiation.
GO - Molecular function
  • cytokine activity : IBA:GO_Central
  • growth factor activity : IEA:UniProtKB-KW
  • identical protein binding : IDA:BHF-UCL
  • protein heterodimerization activity : IEA:Ensembl
  • transforming growth factor beta binding : IDA:BHF-UCL
  • type I transforming growth factor beta receptor binding : IDA:BHF-UCL
  • type II transforming growth factor beta receptor binding : IDA:BHF-UCL
  • type III transforming growth factor beta receptor binding : IMP:AgBase
GO - Biological process
  • activation of MAPK activity : IEA:Ensembl
  • aging : IEA:Ensembl
  • BMP signaling pathway : IBA:GO_Central
  • cell development : IBA:GO_Central
  • cell-cell junction organization : IDA:BHF-UCL
  • detection of hypoxia : IDA:BHF-UCL
  • digestive tract development : IEA:Ensembl
  • embryonic neurocranium morphogenesis : IEA:Ensembl
  • face morphogenesis : IMP:BHF-UCL
  • female pregnancy : IEA:Ensembl
  • frontal suture morphogenesis : IEA:Ensembl
  • in utero embryonic development : ISS:BHF-UCL
  • inner ear development : IEA:Ensembl
  • lung alveolus development : ISS:BHF-UCL
  • mammary gland development : ISS:BHF-UCL
  • negative regulation of cell proliferation : IMP:BHF-UCL
  • negative regulation of macrophage cytokine production : IDA:DFLAT
  • negative regulation of neuron apoptotic process : ISS:BHF-UCL
  • negative regulation of transforming growth factor beta receptor signaling pathway : IEA:Ensembl
  • negative regulation of vascular smooth muscle cell proliferation : IDA:BHF-UCL
  • odontogenesis : NAS:BHF-UCL
  • ossification involved in bone remodeling : IEP:BHF-UCL
  • platelet degranulation : TAS:Reactome
  • positive regulation of apoptotic process : ISS:BHF-UCL
  • positive regulation of bone mineralization : IEP:BHF-UCL
  • positive regulation of cell division : IEA:UniProtKB-KW
  • positive regulation of cell proliferation : IMP:BHF-UCL
  • positive regulation of collagen biosynthetic process : IMP:BHF-UCL
  • positive regulation of epithelial to mesenchymal transition : IDA:BHF-UCL
  • positive regulation of filopodium assembly : ISS:BHF-UCL
  • positive regulation of occluding junction disassembly : IDA:BHF-UCL
  • positive regulation of pathway-restricted SMAD protein phosphorylation : ISS:BHF-UCL
  • positive regulation of protein secretion : IDA:BHF-UCL
  • positive regulation of SMAD protein signal transduction : ISS:BHF-UCL
  • positive regulation of stress fiber assembly : IDA:BHF-UCL
  • positive regulation of transcription by RNA polymerase II : ISS:BHF-UCL
  • positive regulation of transcription, DNA-templated : IDA:BHF-UCL
  • regulation of apoptotic process : IBA:GO_Central
  • regulation of MAPK cascade : IBA:GO_Central
  • response to estrogen : IEA:Ensembl
  • response to hypoxia : IDA:BHF-UCL
  • response to laminar fluid shear stress : IEA:Ensembl
  • response to progesterone : IDA:BHF-UCL
  • salivary gland morphogenesis : IEP:BHF-UCL
  • secondary palate development : ISS:BHF-UCL
  • SMAD protein signal transduction : IBA:GO_Central
  • transforming growth factor beta receptor signaling pathway : IDA:BHF-UCL
  • uterine wall breakdown : TAS:BHF-UCL
  • wound healing : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.