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P10145

Interleukin-8 (P10145)

Uniprot ID P10145
Protein Name Interleukin-8
Gene Name CXCL8
Species Homo sapiens (Human)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.584
Function IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. .
GO - Molecular function
  • chemokine activity : IDA:UniProtKB
  • interleukin-8 receptor binding : IPI:UniProtKB
GO - Biological process
  • angiogenesis : TAS:UniProtKB
  • antimicrobial humoral immune response mediated by antimicrobial peptide : IDA:UniProtKB
  • calcium-mediated signaling : TAS:UniProtKB
  • cell cycle arrest : IDA:UniProtKB
  • cellular response to fibroblast growth factor stimulus : IEP:UniProtKB
  • cellular response to interleukin-1 : IEP:UniProtKB
  • cellular response to lipopolysaccharide : IDA:BHF-UCL
  • cellular response to tumor necrosis factor : IEP:UniProtKB
  • chemokine-mediated signaling pathway : IBA:GO_Central
  • chemotaxis : TAS:UniProtKB
  • cytokine-mediated signaling pathway : TAS:Reactome
  • embryonic digestive tract development : IEP:DFLAT
  • G-protein coupled receptor signaling pathway : TAS:Reactome
  • immune response : IBA:GO_Central
  • induction of positive chemotaxis : IGI:UniProtKB
  • inflammatory response : TAS:UniProtKB
  • intracellular signal transduction : IDA:UniProtKB
  • killing of cells of other organism : IDA:UniProtKB
  • negative regulation of cell proliferation : TAS:ProtInc
  • negative regulation of G-protein coupled receptor protein signaling pathway : IDA:UniProtKB
  • neutrophil activation : IDA:UniProtKB
  • neutrophil chemotaxis : IDA:UniProtKB
  • PERK-mediated unfolded protein response : TAS:Reactome
  • positive regulation of angiogenesis : IDA:CACAO
  • positive regulation of neutrophil chemotaxis : TAS:BHF-UCL
  • receptor internalization : IDA:UniProtKB
  • regulation of cell adhesion : IDA:UniProtKB
  • regulation of entry of bacterium into host cell : IMP:AgBase
  • regulation of single stranded viral RNA replication via double stranded DNA intermediate : IDA:UniProtKB
  • response to endoplasmic reticulum stress : IDA:UniProtKB
  • response to molecule of bacterial origin : IDA:BHF-UCL
  • signal transduction : TAS:ProtInc
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.