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P0C6F1

Dynein heavy chain 2, axonemal (P0C6F1)

Uniprot ID P0C6F1
Protein Name Dynein heavy chain 2, axonemal
Gene Name Dnah2
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.0
Function Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). .
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • ATP-dependent microtubule motor activity, minus-end-directed : IBA:GO_Central
  • dynein intermediate chain binding : IBA:GO_Central
  • dynein light chain binding : IBA:GO_Central
  • dynein light intermediate chain binding : IBA:GO_Central
GO - Biological process
  • microtubule-based movement : IBA:GO_Central
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.