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P09528

Ferritin heavy chain (P09528)

Uniprot ID P09528
Protein Name Ferritin heavy chain
Gene Name Fth1
Species Mus musculus (Mouse)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.664
Function Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. .
GO - Molecular function
  • ferric iron binding : IEA:InterPro
  • ferroxidase activity : IEA:UniProtKB-EC
  • iron ion binding : IDA:MGI
GO - Biological process
  • immune response : ISS:UniProtKB
  • intracellular sequestering of iron ion : ISO:MGI
  • iron ion import : IDA:MGI
  • negative regulation of cell proliferation : ISS:UniProtKB
  • negative regulation of fibroblast proliferation : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.