Galectin-1 (P09382)

Uniprot ID P09382
Protein Name Galectin-1
Gene Name LGALS1
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b) 0.707
Function Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. .
GO - Molecular function
  • lactose binding : IEA:Ensembl
  • laminin binding : IEA:Ensembl
  • protein homodimerization activity : IEA:Ensembl
  • RNA binding : HDA:UniProtKB
GO - Biological process
  • apoptotic process : TAS:ProtInc
  • cellular protein metabolic process : TAS:Reactome
  • cellular response to glucose stimulus : IEA:Ensembl
  • cellular response to organic cyclic compound : IEA:Ensembl
  • myoblast differentiation : IEA:Ensembl
  • negative regulation of cell-substrate adhesion : IEA:Ensembl
  • negative regulation of neuron projection development : IEA:Ensembl
  • plasma cell differentiation : IEA:Ensembl
  • positive regulation of erythrocyte aggregation : IEA:Ensembl
  • positive regulation of I-kappaB kinase/NF-kappaB signaling : HMP:UniProtKB
  • positive regulation of viral entry into host cell : IDA:UniProtKB
  • post-translational protein modification : TAS:Reactome
  • regulation of apoptotic process : TAS:UniProtKB
  • response to axon injury : IEA:Ensembl
  • response to drug : IEA:Ensembl
  • response to isolation stress : IEA:Ensembl
  • T cell costimulation : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.