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P08254

Stromelysin-1 (P08254)

Uniprot ID P08254
Protein Name Stromelysin-1
Gene Name MMP3
Species Homo sapiens (Human)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.469
Function Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
GO - Molecular function
  • endopeptidase activity : IDA:ParkinsonsUK-UCL
  • metalloendopeptidase activity : IBA:GO_Central
  • metallopeptidase activity : IDA:UniProtKB
  • serine-type endopeptidase activity : TAS:Reactome
  • zinc ion binding : IEA:InterPro
GO - Biological process
  • cellular response to nitric oxide : TAS:ParkinsonsUK-UCL
  • collagen catabolic process : IBA:GO_Central
  • cytokine-mediated signaling pathway : TAS:Reactome
  • extracellular matrix disassembly : TAS:Reactome
  • extracellular matrix organization : IBA:GO_Central
  • negative regulation of hydrogen peroxide metabolic process : IDA:ParkinsonsUK-UCL
  • positive regulation of oxidative stress-induced cell death : ISS:ParkinsonsUK-UCL
  • positive regulation of protein complex assembly : IDA:ParkinsonsUK-UCL
  • proteolysis : IDA:UniProtKB
  • regulation of neuroinflammatory response : TAS:ARUK-UCL
  • response to amyloid-beta : TAS:ARUK-UCL
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.