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O95631

Netrin-1 (O95631)

Uniprot ID O95631
Protein Name Netrin-1
Gene Name NTN1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.519
Function Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis (PubMed:15343335). .
GO - Molecular function
GO - Biological process
  • animal organ morphogenesis : IBA:GO_Central
  • anterior/posterior axon guidance : IEA:Ensembl
  • apoptotic process : IEA:UniProtKB-KW
  • Cdc42 protein signal transduction : ISS:UniProtKB
  • cell-cell adhesion : IEA:Ensembl
  • chemorepulsion of axon : ISS:UniProtKB
  • dendrite development : IBA:GO_Central
  • inner ear morphogenesis : IEA:Ensembl
  • mammary gland duct morphogenesis : IEA:Ensembl
  • motor neuron axon guidance : IBA:GO_Central
  • negative regulation of axon extension : IEA:Ensembl
  • negative regulation of netrin-activated signaling pathway : TAS:Reactome
  • neuron migration : IEA:Ensembl
  • nuclear migration : IEA:Ensembl
  • positive regulation of axon extension : ISS:UniProtKB
  • positive regulation of cell motility : ISS:UniProtKB
  • positive regulation of cell population proliferation : IEA:Ensembl
  • Ras protein signal transduction : ISS:UniProtKB
  • regulation of cell migration : IEA:Ensembl
  • regulation of synapse assembly : IEA:Ensembl
  • substrate-dependent cell migration, cell extension : ISS:UniProtKB
  • tissue development : IBA:GO_Central
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.