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O95497

Pantetheinase (O95497)

Uniprot ID O95497
Protein Name Pantetheinase
Gene Name VNN1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.785
Function Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. .
GO - Molecular function
  • pantetheine hydrolase activity : IDA:UniProtKB
GO - Biological process
  • acute inflammatory response : ISS:BHF-UCL
  • cell-cell adhesion : ISS:BHF-UCL
  • chronic inflammatory response : ISS:BHF-UCL
  • inflammatory response : ISS:BHF-UCL
  • innate immune response : ISS:BHF-UCL
  • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway : ISS:BHF-UCL
  • neutrophil degranulation : TAS:Reactome
  • pantothenate metabolic process : IDA:UniProtKB
  • positive regulation of T cell differentiation in thymus : ISS:BHF-UCL
  • response to oxidative stress : TAS:BHF-UCL
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.