Uniprot ID | O95390 | ||
Protein Name | Growth/differentiation factor 11 | ||
Gene Name | GDF11 | ||
Species | Homo sapiens (Human) |
Signal peptide(a) | Y | Secretome P(b) | 0.909 |
Function | Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. May play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern (By similarity). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:28257634). . | ||
GO - Molecular function |
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GO - Biological process |
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