| Signal peptide(a) |
N |
Secretome P(b) |
0.893 |
| Function |
Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan. . |
| GO - Molecular function |
- heparin binding : IBA:GO_Central
- insulin-like growth factor binding : IEA:InterPro
- integrin binding : IBA:GO_Central
|
| GO - Biological process |
- bone development : IEA:Ensembl
- cell adhesion : IBA:GO_Central
- cell-cell signaling : TAS:ProtInc
- glucose homeostasis : IEA:Ensembl
- negative regulation of cell death : IBA:GO_Central
- negative regulation of chondrocyte differentiation : IEA:Ensembl
- negative regulation of fat cell differentiation : IEA:Ensembl
- osteoblast differentiation : IEA:Ensembl
- osteoclast differentiation : IEA:Ensembl
- positive regulation of inflammatory response : IDA:UniProtKB
- positive regulation of osteoblast differentiation : IMP:UniProtKB
- positive regulation of smooth muscle cell migration : ISS:UniProtKB
- positive regulation of smooth muscle cell proliferation : ISS:UniProtKB
- positive regulation of Wnt signaling pathway : IEA:Ensembl
- positive regulation of wound healing : IEA:Ensembl
- regulation of cytokine secretion : IDA:UniProtKB
- signal transduction : TAS:ProtInc
- Wnt signaling pathway : IEA:UniProtKB-KW
|