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O95243

Methyl-CpG-binding domain protein 4 (O95243)

Uniprot ID O95243
Protein Name Methyl-CpG-binding domain protein 4
Gene Name MBD4
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.539
Function Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. .
GO - Molecular function
  • DNA binding : IBA:GO_Central
  • DNA N-glycosylase activity : TAS:Reactome
  • endodeoxyribonuclease activity : TAS:ProtInc
  • pyrimidine-specific mismatch base pair DNA N-glycosylase activity : IDA:MGI
  • satellite DNA binding : TAS:ProtInc
GO - Biological process
  • depyrimidination : TAS:Reactome
  • DNA repair : TAS:ProtInc
  • response to estradiol : IEA:Ensembl
  • response to radiation : IBA:GO_Central
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.