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O94855

Protein transport protein Sec24D (O94855)

Uniprot ID O94855
Protein Name Protein transport protein Sec24D
Gene Name SEC24D
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.666
Function Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:20427317, PubMed:18843296). Plays a central role in cargo selection within the COPII complex and together with SEC24C may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:20427317, PubMed:18843296). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296). .
GO - Molecular function
  • SNARE binding : IPI:UniProtKB
  • zinc ion binding : IDA:UniProtKB
GO - Biological process
  • antigen processing and presentation of exogenous peptide antigen via MHC class II : TAS:Reactome
  • antigen processing and presentation of peptide antigen via MHC class I : TAS:Reactome
  • COPII vesicle coating : TAS:Reactome
  • COPII-coated vesicle cargo loading : IDA:UniProtKB
  • endoplasmic reticulum to Golgi vesicle-mediated transport : IMP:UniProtKB
  • in utero embryonic development : IEA:Ensembl
  • intracellular protein transport : IEA:InterPro
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.