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O88508

DNA (cytosine-5)-methyltransferase 3A (O88508)

Uniprot ID O88508
Protein Name DNA (cytosine-5)-methyltransferase 3A
Gene Name Dnmt3a
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (2) Interactions
Signal peptide(a) N Secretome P(b) 0.346
Function Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. .
GO - Molecular function
  • chromatin binding : IDA:MGI
  • DNA (cytosine-5-)-methyltransferase activity : IDA:MGI
  • DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates : TAS:Reactome
  • DNA binding : IDA:MGI
  • identical protein binding : ISO:MGI
  • metal ion binding : IEA:UniProtKB-KW
  • methyltransferase activity : TAS:MGI
GO - Biological process
  • aging : IEA:Ensembl
  • cellular response to amino acid stimulus : IDA:MGI
  • cellular response to ethanol : IEA:Ensembl
  • cellular response to hypoxia : IEA:Ensembl
  • DNA methylation : IDA:MGI
  • DNA methylation involved in embryo development : IMP:UniProtKB
  • DNA methylation involved in gamete generation : IMP:UniProtKB
  • DNA methylation on cytosine : ISO:MGI
  • hepatocyte apoptotic process : IEA:Ensembl
  • hypermethylation of CpG island : IDA:BHF-UCL
  • maintenance of DNA methylation : TAS:BHF-UCL
  • methylation-dependent chromatin silencing : IDA:MGI
  • mitotic cell cycle : IEA:Ensembl
  • negative regulation of transcription by RNA polymerase II : IDA:MGI
  • neuron differentiation : IEA:Ensembl
  • positive regulation of cell death : ISO:MGI
  • regulation of gene expression by genetic imprinting : IDA:BHF-UCL
  • response to cocaine : IEA:Ensembl
  • response to estradiol : IEA:Ensembl
  • response to ionizing radiation : IEA:Ensembl
  • response to lead ion : IEA:Ensembl
  • response to vitamin A : IEA:Ensembl
  • spermatogenesis : IMP:MGI
  • transcription, DNA-templated : IEA:UniProtKB-KW
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.